منابع مشابه
Targeting microRNAs in heart failure.
MicroRNAs play pivotal roles in cardiac disease, and their therapeutic modulation raises exciting and unique opportunities, as well as challenges in the path toward clinical development and implementation. In this review, we provide a detailed overview of recent studies highlighting the important role of microRNAs in heart failure (HF) and the potential use of microRNA-based technology for diag...
متن کاملThe Prevalence of Anemia in Elderly With Systolic Heart Failure
Objectives: Anemia is prevalent in heart failures and is an independent risk factor for adverse clinical outcomes in patients with CHF. The aim of the present study was to determine the prevalence of anemia in elderly with systolic heart failure hospitalized in Alborz Hospital of Karaj in 2009. Methods & Materials: This is a descriptive retrospective study that reviewed 154 medical records o...
متن کاملTargeting Cardiomyocyte Ca2+ Homeostasis in Heart Failure
Improved treatments for heart failure patients will require the development of novel therapeutic strategies that target basal disease mechanisms. Disrupted cardiomyocyte Ca(2+) homeostasis is recognized as a major contributor to the heart failure phenotype, as it plays a key role in systolic and diastolic dysfunction, arrhythmogenesis, and hypertrophy and apoptosis signaling. In this review, we...
متن کاملTargeting Mitochondrial Oxidative Stress in Heart Failure
Oxidative stress contributes to various cardiovascular diseases and aging and was causally linked to the progression of heart failure (1,2). Among the most relevant sources for reactive oxygen species (ROS) are nicotinamide adenine dinucleotide phosphate (NADPH) oxidases and mitochondria (1,3–7). The ROS impair excitation-contraction coupling, cause arrhythmias, and contribute to cardiac remode...
متن کاملTargeting oxidative stress in heart failure
Increased oxidative stress is recognized to be important in the pathogenesis of cardiovascular disease, including heart failure. Reactive oxygen species (ROS) can be derived from diverse sources, including mitochondria, NADPH oxidase, and xanthine oxidase. Many agents established in the treatment of heart failure (including angiotensin-converting enzyme inhibitors, statins, b-blockers, hydralaz...
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ژورنال
عنوان ژورنال: JACC: Heart Failure
سال: 2015
ISSN: 2213-1779
DOI: 10.1016/j.jchf.2015.04.011